49ers vs Lions Week 1 Picks and Predictions: Can New Detroit Brass Keep Things Close?

One of the biggest spreads on the NFL betting board for Week 1 is a clash between the San Francisco 49ers and Detriot Lions, with the Niners installed as 8-point road favorites.

San Fran had an injury-plagued 2020 season and aims to bounce back with a return to the playoffs. The Lions might be ideal early-season fodder as they rebuild with a new quarterback and coach, and have the second-lowest win total of 2021 at an O/U of 4.5. 

Here are our best free 49ers vs. Lions picks and predictions for Sunday, September 12, with kickoff at 1 p.m. ET. 

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